Massively parallel gene expression variation measurement of a synonymous codon library
نویسندگان
چکیده
منابع مشابه
Gene expression profiling by massively parallel sequencing.
Massively parallel sequencing holds great promise for expression profiling, as it combines the high throughput of SAGE with the accuracy of EST sequencing. Nevertheless, until now only very limited information had been available on the suitability of the current technology to meet the requirements. Here, we evaluate the potential of 454 sequencing technology for expression profiling using Droso...
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Background: Little knowledge of synonymous codon usage pattern of pseudorabies virus (PRV) genome, especially the UL31 gene in the process for its evolution is available. Objectives: In the present study, the codon usage bias between PRV UL31 sequence and the UL31-like sequences was identified. Materials and Methods: We used a comprehensive analysi...
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In unicellular organisms, synonymous codon bias is correlated with the level of gene expression [1]. The codon bias becomes stronger in genes with higher expression levels. It becomes weaker but still remains in genes with lower expression levels. The bias means that synonymous codons are not used at random. In highly expressed genes, the synonymous codon usage is mainly determined by an abunda...
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SUMMARY Efficient workflows to shepherd clinically generated genomic data through the multiple stages of a next-generation sequencing pipeline are of critical importance in translational biomedical science. Here we present COSMOS, a Python library for workflow management that allows formal description of pipelines and partitioning of jobs. In addition, it includes a user interface for tracking ...
متن کاملSynonymous Codon Substitution Matrices
Observing differences between DNA or protein sequences and estimating the true amount of substitutions from them is a prominent problem in molecular evolution as many analyses are based on distance measures between biological sequences. Since the relationship between the observed and the actual amount of mutations is very complex, more than four decades of research have been spent to improve mo...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2021
ISSN: 1471-2164
DOI: 10.1186/s12864-021-07462-z